Vehicles for gene therapy

Stem cells as cellular vehicles for gene therapy against glioblastoma.

Glioblastoma (GBM) is the most common and deadliest primary tumor in adults, with current treatments having limited specific and efficient delivery of therapeutic drugs to tumor sites or cells. Therefore, the development of alternative treatment options is urgently needed. Stem cells are considered as ideal cellular vehicles for gene therapy against glioblastoma. In this paper, we reviewed the ...

Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles

Immunostimulatory gene therapy has been developed during the past twenty years. The aim of immunostimulatory gene therapy is to tilt the suppressive tumor microenvironment to promote anti-tumor immunity. Hence, like a Trojan horse, the gene vehicle can carry warriors and weapons into enemy territory to combat the tumor from within. The most promising immune stimulators are those activating and ...

tosensitizer Vehicles for Photodynamic Cancer Therapy

Downlo mentous M13 phage can be engineered to display cancer cell–targeting or tumor-homing peptides h phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer to deliver them to the cancer cells. We studied the evolution of structures of the complexes between c filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric pho...

ژن درمانی Gene Therapy

Stem cells as cellular vehicles for gene therapy against glioblastoma. - PubMed - NCBI

Abstract Glioblastoma (GBM) is the most common and deadliest primary tumor in adults, with current treatments having limited specific and efficient delivery of therapeutic drugs to tumor sites or cells. Therefore, the development of alternative treatment options is urgently needed. Stem cells are considered as ideal cellular vehicles for gene therapy against glioblastoma. In this paper, we revi...